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Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions

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Abstract

A convenient and efficient method for the synthesis of 2-halogen-substituted pyridines is described. The decarboxylative halogenation of 2-picolinic acids with dihalomethane proceeded smoothly via N-chlorocarbene intermediates to afford 2-halogen-substituted pyridines in satisfactory to excellent yields under transition-metal-free conditions. This new type of decarboxylative halogenation is operationally simple and exhibits high functional-group tolerance.

Graphical abstract: Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions

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Publication details

The article was received on 14 Jul 2019, accepted on 05 Sep 2019 and first published on 09 Sep 2019


Article type: Paper
DOI: 10.1039/C9GC02407G
Green Chem., 2019, Advance Article

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    Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions

    X. Zhang, X. Feng, H. Zhang, Y. Yamamoto and M. Bao, Green Chem., 2019, Advance Article , DOI: 10.1039/C9GC02407G

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