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Nano Au/Pd-catalysed ‘on-water’ synthesis of C3–C3′ diaryl-oxindole scaffolds via N2-selective dearomatization of indole

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Abstract

‘On-water’ synthesis of 2,2-bis(indoly-3-yl)indoline-3-ones via N2-selective dearomatization of ‘(N–H) protection-free’ indole derivatives is described. An oxidative homo trimerization of indole via nano Au/Pd catalysis with oxone as additive was successfully demonstrated for the first time. In situ generation of isatin at room temperature and with water as solvent are key features.

Graphical abstract: Nano Au/Pd-catalysed ‘on-water’ synthesis of C3–C3′ diaryl-oxindole scaffolds via N2-selective dearomatization of indole

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Publication details

The article was received on 11 Jul 2019, accepted on 16 Nov 2019 and first published on 22 Nov 2019


Article type: Paper
DOI: 10.1039/C9GC02370D
Green Chem., 2019, Advance Article

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    Nano Au/Pd-catalysed ‘on-water’ synthesis of C3–C3′ diaryl-oxindole scaffolds via N2-selective dearomatization of indole

    S. B. Gohain, M. Basumatary, P. K. Boruah, M. R. Das and A. J. Thakur, Green Chem., 2019, Advance Article , DOI: 10.1039/C9GC02370D

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