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Issue 18, 2019
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A biocatalytic cascade for the conversion of fatty acids to fatty amines

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Abstract

Fatty amine synthesis from renewable sources is an energetically-demanding process involving toxic metal catalysts and harsh reaction conditions as well as selectivity problems. Herein we present a mild, biocatalytic alternative to the conventional amination of fatty acids through a one-pot tandem cascade performed by a carboxylic acid reductase (CAR) and a transaminase (ω-TA). Saturated and unsaturated fatty acids, with carbon chain lengths ranging from C6 to C18, were successfully aminated obtaining conversions of up to 96%.

Graphical abstract: A biocatalytic cascade for the conversion of fatty acids to fatty amines

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Submitted
03 Jul 2019
Accepted
30 Aug 2019
First published
30 Aug 2019

Green Chem., 2019,21, 4932-4935
Article type
Communication

A biocatalytic cascade for the conversion of fatty acids to fatty amines

J. Citoler, S. R. Derrington, J. L. Galman, H. Bevinakatti and N. J. Turner, Green Chem., 2019, 21, 4932
DOI: 10.1039/C9GC02260K

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