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Biofactories: engineered nanoparticles via genetically engineered organisms

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Nanoparticles and nanostructures are being applied in a diverse range of biomedical and pharmaceutical applications, including targeted drug- and gene-delivery systems, cancer therapy, anti-virus and antimicrobial agents, RNA and DNA analyses, biosensors, catalysis, and imaging. In the context of nanoparticles and their assembly, organism-centered biosynthesis propounds additional energy-efficiency, safer, greener, and environmentally-friendly protocols in contrast to the physico-chemical procedures necessitating the use of solvents and unsafe/toxic materials, often at elevated temperatures. Genetically engineered organisms can be applied as good candidates for greener, eco-friendly, expeditious, high-throughput, and versatile bioreduction systems for the synthesis and assembly of nanomaterials and NPs, even on the industrial scale. In terms of ideal attributes, they should be much more resistant to metal toxicity, grow rapidly in inexpensive simple media, produce higher yields of biomass and can be easily manipulated genetically. In this review, the latest advances in nanoparticle biosynthesis are highlighted with particular emphasis on the deployment of genetically engineered organisms. The challenges and future trends in this field are accentuated, where innovative and engineered approaches will be the most consequential.

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The article was received on 27 May 2019, accepted on 23 Jul 2019 and first published on 29 Jul 2019

Article type: Critical Review
DOI: 10.1039/C9GC01759C
Green Chem., 2019, Advance Article

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    Biofactories: engineered nanoparticles via genetically engineered organisms

    S. Iravani and R. S. Varma, Green Chem., 2019, Advance Article , DOI: 10.1039/C9GC01759C

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