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Why we might be misusing process mass intensity (PMI) and a methodology to apply it effectively as a discovery level metric

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Abstract

Process mass intensity (PMI) is a key mass-based metric to evaluate the green credentials of an individual or sequence of reactions during process and chemical development. The increasing awareness to consider greenness as early as the initial discovery level, requires a set of parameters suitable to assess it at this stage of development, and guidelines to apply them correctly. This paper evaluates when and how PMI can be used in a correct manner. Different simulations for key reactions in the organic synthesis toolbox – i.e. amide bond formation and Mitsunobu reactions – illustrate that PMI can easily be misleading without due consideration of yield, concentration and molecular weight of reactants and product. A fair appraisal of the green potential of different methodologies therefore requires careful analysis of the examples and metrics data generated.

Graphical abstract: Why we might be misusing process mass intensity (PMI) and a methodology to apply it effectively as a discovery level metric

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Publication details

The article was received on 08 May 2019, accepted on 07 Nov 2019 and first published on 07 Nov 2019


Article type: Paper
DOI: 10.1039/C9GC01537J
Green Chem., 2019, Advance Article

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    Why we might be misusing process mass intensity (PMI) and a methodology to apply it effectively as a discovery level metric

    E. R. Monteith, P. Mampuys, L. Summerton, J. H. Clark, B. U. W. Maes and C. R. McElroy, Green Chem., 2019, Advance Article , DOI: 10.1039/C9GC01537J

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