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Issue 12, 2019
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Flow-based enzymatic synthesis of melatonin and other high value tryptamine derivatives: a five-minute intensified process

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Abstract

To increase the uptake of biocatalytic processes by industry, it is essential to demonstrate the reliability of enzyme-based methodologies directly applied to the production of high value products. Here, a unique, efficient, and sustainable enzymatic platform for the multi-gram synthesis of melatonin, projected to generate around 1.5 billion U.S. dollars worldwide by 2021, and its analogues was developed. The system exploits the covalent immobilization of MsAcT (transferase from Mycobacterium smegmatis) onto agarose beads increasing the robustness and longevity of the immobilized biocatalyst. The fully-automated process deriving from the integration between biocatalysis and flow chemistry is designed to maximize the overall yields (58–92%) and reduce reaction times (5 min), overcoming the limitation often associated with bioprocesses and bridging the gap between lab scale and industrial production.

Graphical abstract: Flow-based enzymatic synthesis of melatonin and other high value tryptamine derivatives: a five-minute intensified process

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Publication details

The article was received on 25 Apr 2019, accepted on 29 May 2019 and first published on 31 May 2019


Article type: Communication
DOI: 10.1039/C9GC01374A
Green Chem., 2019,21, 3263-3266
  • Open access: Creative Commons BY-NC license
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    Flow-based enzymatic synthesis of melatonin and other high value tryptamine derivatives: a five-minute intensified process

    M. L. Contente, S. Farris, L. Tamborini, F. Molinari and F. Paradisi, Green Chem., 2019, 21, 3263
    DOI: 10.1039/C9GC01374A

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