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A facile method for hydroxytrifluoromethylation of alkenes with Langlois reagent and DMSO

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Abstract

A practical hydroxytrifluoromethylation of alkenes using the Langlois reagent as the trifluoromethyl source and DMSO as the oxidant is described. This reaction is mild and operationally simple, without exclusion of either moisture or oxygen, allowing access to a wide range of β-trifluoromethyl alcohols in useful yields. This transformation is environmentally friendly and can be easily scaled up to gram level.

Graphical abstract: A facile method for hydroxytrifluoromethylation of alkenes with Langlois reagent and DMSO

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Publication details

The article was received on 14 Mar 2019, accepted on 22 Apr 2019 and first published on 24 Apr 2019


Article type: Paper
DOI: 10.1039/C9GC00886A
Green Chem., 2019, Advance Article

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    A facile method for hydroxytrifluoromethylation of alkenes with Langlois reagent and DMSO

    W. Shen, Q. Wu, X. Gong, G. Ao and F. Liu, Green Chem., 2019, Advance Article , DOI: 10.1039/C9GC00886A

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