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Issue 9, 2019
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Strecker reactions with hexacyanoferrates as non-toxic cyanide sources

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Abstract

The Strecker reaction is the most widely applied three-component reaction. Although highly useful for the preparation of α-amino nitriles, α-amino acids, hydantoins and numerous related compounds, the need for the application of toxic sources of HCN limits its application in both academic and industrial settings. Here, we present a facile protocol for Strecker reactions using a mixture of potassium ferri- and ferrocyanides as a non-toxic substitute.

Graphical abstract: Strecker reactions with hexacyanoferrates as non-toxic cyanide sources

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Article information


Submitted
27 Feb 2019
Accepted
22 Mar 2019
First published
22 Mar 2019

Green Chem., 2019,21, 2362-2366
Article type
Paper

Strecker reactions with hexacyanoferrates as non-toxic cyanide sources

C. Grundke and T. Opatz, Green Chem., 2019, 21, 2362
DOI: 10.1039/C9GC00720B

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