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NHC ligand-enabled Ni-catalyzed reductive coupling of alkynes and imines using isopropanol as a reductant

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Abstract

A nickel-catalyzed reductive coupling of alkynes and imines using readily available isopropanol as the reducing agent was developed. The use of a sterically bulky and electron-rich carbene ligand (AnIPr) significantly promotes the reaction, providing various multi-substituted allylic amines in 23–89% yield and the corresponding chiral ligand (AnIPr-3) can afford the products in 51–95% ee.

Graphical abstract: NHC ligand-enabled Ni-catalyzed reductive coupling of alkynes and imines using isopropanol as a reductant

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Publication details

The article was received on 22 Feb 2019, accepted on 28 Mar 2019 and first published on 28 Mar 2019


Article type: Communication
DOI: 10.1039/C9GC00653B
Citation: Green Chem., 2019, Advance Article

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    NHC ligand-enabled Ni-catalyzed reductive coupling of alkynes and imines using isopropanol as a reductant

    W. Yao, R. Li, J. Li, J. Sun and M. Ye, Green Chem., 2019, Advance Article , DOI: 10.1039/C9GC00653B

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