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Issue 9, 2019
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Solvent effects in palladium catalysed cross-coupling reactions

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Abstract

Palladium catalysed cross-couplings reactions have been a dominant method in synthetic chemistry for decades. Despite this, the role of the solvent is often taken for granted and poorly understood. Regulations affecting some the most frequently used solvents for cross-coupling reactions are accelerating current trends towards using new types of solvents. In this review, the fundamental interactions between solvent and catalyst are explained so that it may inform the rational selection of high performance and safe solvents. The popular cross-coupling methodologies are addressed (Suzuki, Stille, Kumada, Negishi, Hiyama, Heck, Sonogashira, and Buchwald–Hartwig reactions) and novel solvents introduced.

Graphical abstract: Solvent effects in palladium catalysed cross-coupling reactions

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Publication details

The article was received on 19 Feb 2019, accepted on 03 Apr 2019 and first published on 08 Apr 2019


Article type: Critical Review
DOI: 10.1039/C9GC00617F
Green Chem., 2019,21, 2164-2213

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    Solvent effects in palladium catalysed cross-coupling reactions

    J. Sherwood, J. H. Clark, I. J. S. Fairlamb and J. M. Slattery, Green Chem., 2019, 21, 2164
    DOI: 10.1039/C9GC00617F

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