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A designer natural deep eutectic solvent to recycle the cofactor in alcohol dehydrogenase-catalysed processes.

Abstract

Deep eutectic solvents (DES) represent nowadays a sustainable alternative to traditional organic solvents in (bio)transformations. Herein, the use of a solvent composed by an aqueous buffer and choline chloride: glucose (1.5:1 mol/mol) is proposed, a natural DES (NADES) serving as both cosolvent and efficient system to recycle the nicotinamide cofactor. Thus, glucose from NADES served as co-substrate required for several alcohol dehydrogenases to reduce different prochiral ketones, and also helped to solubilise the organic compounds to develop effective biotransformations at higher substrate concentrations.

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Publication details

The article was received on 27 Jan 2019, accepted on 13 May 2019 and first published on 13 May 2019


Article type: Communication
DOI: 10.1039/C9GC00318E
Green Chem., 2019, Accepted Manuscript

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    A designer natural deep eutectic solvent to recycle the cofactor in alcohol dehydrogenase-catalysed processes.

    Á. Mourelle-Insua, I. Lavandera and V. Gotor-Fernandez, Green Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9GC00318E

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