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Issue 4, 2019
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Photogenerated acyl/alkoxycarbonyl/carbamoyl radicals for sustainable synthesis

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Abstract

Acylation reactions are of crucial importance in synthesis since they provide access to ketones or related derivatives. The well known acylations of aromatics (the Friedel–Crafts reaction) or olefins are commonly carried out under harsh and/or non-sustainable conditions. An alternative approach consists in the use of acyl (or related) radicals as acylating agents. Recently, the photochemical approach has been proposed as a green route for the generation of acyl/alkoxycarbonyl/carbamoyl radicals and their application in synthesis due to the mildness of the conditions employed. The reactions are mostly carried out at room temperature by using inexpensive visible or solar light. This article offers an overview on the photochemical/photocatalyzed pathways that allow the introduction of the acyl group in aromatics, alkenes and alkynes.

Graphical abstract: Photogenerated acyl/alkoxycarbonyl/carbamoyl radicals for sustainable synthesis

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Publication details

The article was received on 06 Dec 2018, accepted on 17 Jan 2019 and first published on 17 Jan 2019


Article type: Perspective
DOI: 10.1039/C8GC03810D
Citation: Green Chem., 2019,21, 748-764

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    Photogenerated acyl/alkoxycarbonyl/carbamoyl radicals for sustainable synthesis

    C. Raviola, S. Protti, D. Ravelli and M. Fagnoni, Green Chem., 2019, 21, 748
    DOI: 10.1039/C8GC03810D

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