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Issue 4, 2019
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Electrochemical oxidation synergizing with Brønsted-acid catalysis leads to [4 + 2] annulation for the synthesis of pyrazines

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Abstract

An electrochemical dehydrogenative [4 + 2] annulation for the synthesis of pyrazines has been developed under undivided electrolytic conditions. In this protocol, neither external chemical oxidants nor transition-metal catalysts are needed, and a wide range of substituted pyrazines could be obtained from simple ketones and diamines in high efficiencies. Of note is that this electrolysis could also be extended for the construction of biheteroarenes and large π systems with good yields.

Graphical abstract: Electrochemical oxidation synergizing with Brønsted-acid catalysis leads to [4 + 2] annulation for the synthesis of pyrazines

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Publication details

The article was received on 04 Dec 2018, accepted on 13 Jan 2019 and first published on 15 Jan 2019


Article type: Communication
DOI: 10.1039/C8GC03786H
Citation: Green Chem., 2019,21, 765-769

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    Electrochemical oxidation synergizing with Brønsted-acid catalysis leads to [4 + 2] annulation for the synthesis of pyrazines

    K. Liu, C. Song, J. Wu, Y. Deng, S. Tang and A. Lei, Green Chem., 2019, 21, 765
    DOI: 10.1039/C8GC03786H

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