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A one-pot catalyst/external oxidant/solvent-free cascade approach to pyrimidines via a 1,5-hydride transfer

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Abstract

A cascade 3-component reaction of 6-aminouracil, aldehyde and tetrahydroisoquinolines under heating in the absence of catalyst, external oxidant and solvent is performed. The reaction constructs a new pyrimidine ring by the functionalization of the C–H bond adjacent to nitrogen through a 1,5-hydride shift. No chromatographic techniques were required to purify the products.

Graphical abstract: A one-pot catalyst/external oxidant/solvent-free cascade approach to pyrimidines via a 1,5-hydride transfer

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Publication details

The article was received on 09 Nov 2018, accepted on 20 Nov 2018 and first published on 05 Dec 2018


Article type: Communication
DOI: 10.1039/C8GC03507E
Citation: Green Chem., 2019, Advance Article
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    A one-pot catalyst/external oxidant/solvent-free cascade approach to pyrimidines via a 1,5-hydride transfer

    M. L. Deb, P. J. Borpatra and P. K. Baruah, Green Chem., 2019, Advance Article , DOI: 10.1039/C8GC03507E

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