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Effect of antibiotic-free, low-protein diet with specific amino acid compositions on growth and intestinal flora in weaned pigs

Abstract

This study investigated the effects of modulation of amino acid profile on growth performance and gut health in weaned pigs fed the antibiotic-free, low-protein diet. In experiment 1, 5 treatments were included: a control diet with antibiotics; a low-protein diet with antibiotics; a low-protein diet without antibiotics (LP); LP diet with 10% more dietary essential amino acids (LP110); and LP110 diet with 12% more dietary Met + Cys, Thr and Trp. The intestinal digestive enzyme activity and morphology were improved with the increase in dietary essential amino acid levels, while the growth performance was decreased, indicating that dietary amino acid level was too high. In experiment 2, all 5 treatments in experiment 1 were included, plus LP diet with 5% more dietary essential amino acids (LP105) and LP105 diet with 6% more dietary Met + Cys, Thr and Trp. The LP105 treatment showed optimal feed efficiency, a reduced plasma endotoxin concentration, and an increased fecal lactate concentration and increased abundances of Prevotellaceae and Roseburia bacteria. Our results demonstrate that the optimal amino acid profile in an antibiotic-free, low-protein diet can efficiently improve growth performance and gut health and modulate the fecal microbial structure in weaned pigs.

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Publication details

The article was accepted on 30 Nov 2019 and first published on 02 Dec 2019


Article type: Paper
DOI: 10.1039/C9FO02724F
Food Funct., 2019, Accepted Manuscript

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    Effect of antibiotic-free, low-protein diet with specific amino acid compositions on growth and intestinal flora in weaned pigs

    J. Zhou, Y. Wang, X. Zeng, T. Zhang, P. Li, B. Yao, L. Wang, S. Qiao and X. Zeng, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C9FO02724F

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