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Hypoglycemic effects of polysaccharides from Gomphidiaceae rutilus fruiting bodies and their mechanisms

Abstract

Insulin resistance is the main cause of type 2 diabetes, fatty liver and obesity. Our previous study found mushroom polysaccharides have improved insulin resistance in vitro, but the underlying mechanisms were still unknown. Thus, we investigate the hypoglycemic effects of polysaccharides from Gomphidiaceae rutilus fruiting bodies and the mechanisms. The total polysaccharide (AGRP) and the neutral polysaccharide (AGRP-N) enhance insulin-stimulated glucose uptake in autophagy-dependent manner on high glucose and fatty acids-treated hepatic cells, but not the acidic polysaccharide (AGRP-A). Further, we elevate the oral hypoglycemic effects of polysaccharides on ob/ob mice. AGRP and AGRP-N lower blood glucose and improve insulin sensitivity. They inhibit liver lipid deposition, not only by activating AMPK to increase autophagy, but also by increasing the expressions of PPARĪ± and CPT-1a to enhance lipolysis. Our results provide basis for the development of polysaccharides from Gomphidiaceae rutilus as hypoglycemic healthy food.

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Publication details

The article was received on 30 Sep 2019, accepted on 24 Nov 2019 and first published on 29 Nov 2019


Article type: Paper
DOI: 10.1039/C9FO02283J
Food Funct., 2019, Accepted Manuscript

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    Hypoglycemic effects of polysaccharides from Gomphidiaceae rutilus fruiting bodies and their mechanisms

    S. Yang, Y. Qu, H. Zhang, Z. Xue, T. Liu, L. Yang, L. Sun, Y. Zhou and Y. Fan, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C9FO02283J

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