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Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

Abstract

Anti-inflammatory properties of artichoke pectin and modified fractions (arabinose- and galactose-free) used at two doses (40 and 80 mg kg-1) in mice with colitis induced by dextran sulfate sodium has been investigated. Pro-inflammatory markers TNF-α and ICAM-I expression decreased in groups of mice treated with original and arabinose-free artichoke pectin while IL-1β and IL-6 liberation was reduced only in mice groups treated with original artichoke pectin. A decrease in iNOS and TLR-4 expression was observed for most treatments. Intestinal barrier genes expression was also determined. MUC-1 and Occludin increased in groups treated with original artichoke pectin while MUC-3 expression also increased in arabinose-free pectin treatment. Galactose elimination led to a loss of pectin bioactivity. Characteristic expression profiles were established for each treatment through artificial neural networks showing high accuracy rates (≥90%). These results highlight the potential amelioration of inflammatory bowel disease on mice model colitis through artichoke pectin administration.

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Publication details

The article was received on 23 Sep 2019, accepted on 30 Oct 2019 and first published on 31 Oct 2019


Article type: Paper
DOI: 10.1039/C9FO02221J
Food Funct., 2019, Accepted Manuscript
  • Open access: Creative Commons BY-NC license
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    Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

    C. Sabater, J. A. Molina-Tijeras, T. Vezza, N. Corzo, A. Montilla and M. P. Utrilla, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C9FO02221J

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