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Issue 12, 2019
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The protective effect of Sargassum horneri against particulate matter-induced inflammation in lung tissues of an in vivo mouse asthma model

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Abstract

Sargassum horneri is an edible brown seaweed with potential anti-inflammatory properties. The present study was designed to evaluate the anti-inflammatory properties of S. horneri using an in vivo mouse asthma model following exposure to particulate matter (PM). 7–8 week old BALB/c mice (20–25 g) were randomly divided into seven groups (n = 4) as follows: 1: no treatment, 2: OVA (ovalbumin) + PM, 3: OVA + PM + SHE (S. horneri ethanol extract) 200 mg kg−1, 4: OVA + PM + SHE 400 mg kg−1, 5: OVA + PM + prednisone 5 mg kg−1, 6: OVA only, and 7: PM only. All mice (except healthy controls) were sensitized on the first day by intraperitoneal injection of 10 μg OVA and 2 mg Al(OH)3 in 200 μL of saline. Starting from day 15, mice (except groups 1 and 6) were exposed to sonicated PM (5 mg m−3, 30 min day−1) through a nebulizer daily for 7 consecutive days. Mice exposed to PM and OVA showed up-regulated expression of MAPKs and pro-inflammatory cytokine production in the lungs. Furthermore, PM-exposed lungs had significantly reduced expression of Nrf2 and HO-1 genes. However, oral administration of the SHE reduced the phosphorylation levels of MAPKs, iNOS and COX2 expression levels, and mRNA expression levels of pro-inflammatory cytokines. In addition, SHE treated group mice had up-regulated anti-oxidant gene expression levels in the lungs compared to group 2. These findings demonstrate that oral administration of the SHE re-establishes PM-induced inflammation and oxidative stress in the lungs. Taken together, the SHE has therapeutic potential in preventing PM-induced inflammation and oxidative stress.

Graphical abstract: The protective effect of Sargassum horneri against particulate matter-induced inflammation in lung tissues of an in vivo mouse asthma model

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Publication details

The article was received on 06 Sep 2019, accepted on 07 Nov 2019 and first published on 26 Nov 2019


Article type: Paper
DOI: 10.1039/C9FO02068C
Food Funct., 2019,10, 7995-8004

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    The protective effect of Sargassum horneri against particulate matter-induced inflammation in lung tissues of an in vivo mouse asthma model

    K. K. A. Sanjeewa, T. U. Jayawardena, H. G. Lee, K. H. I. N. M. Herath, Y. Jee and Y. Jeon, Food Funct., 2019, 10, 7995
    DOI: 10.1039/C9FO02068C

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