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Issue 11, 2019
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Protective effects of hydroalcoholic extracts from an ancient apple variety ‘Mela Rosa dei Monti Sibillini’ against renal ischemia/reperfusion injury in rats

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Abstract

The purpose of this work was to investigate the effect of hydroalcoholic extracts from the peel (APE) and pulp (APP) of a traditional apple variety of central Italy, the ‘Mela Rosa dei Monti Sibillini’, on the damage caused by renal ischemia/reperfusion injury (IRI) in rats. Thirty mg per kg b.w. of the extracts were administered intraperitoneally to male adult Wistar rats 3 days before the induction of IRI by pedicle clamping. A significant decrease in the levels of malondialdehyde (MDA), tumor necrosis factor-α (TNFα), interleukin 1 beta (IL-1β) and nuclear factor-κB (NF-κB) was observed in the groups pre-treated with APE when compared with IRI rats. The chemical composition of APE was determined by HPLC-DAD-MSn highlighting a significant amount of proanthocyanidins (52.9 mg g−1), flavonols (42.27 mg g−1) and dihydrochalcones (11.75 mg g−1). These findings indicated that this ancient apple variety is a promising source of nutraceuticals and functional foods helpful to manage complications of renal disorders.

Graphical abstract: Protective effects of hydroalcoholic extracts from an ancient apple variety ‘Mela Rosa dei Monti Sibillini’ against renal ischemia/reperfusion injury in rats

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Publication details

The article was received on 24 Jul 2019, accepted on 20 Oct 2019 and first published on 21 Oct 2019


Article type: Paper
DOI: 10.1039/C9FO01635J
Food Funct., 2019,10, 7544-7552

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    Protective effects of hydroalcoholic extracts from an ancient apple variety ‘Mela Rosa dei Monti Sibillini’ against renal ischemia/reperfusion injury in rats

    H. Yousefi-Manesh, S. Hemmati, S. Shirooie, S. M. Nabavi, A. Talebzadeh Bonakdar, R. Fayaznia, M. Hossein Asgardoon, A. Zare Dehnavi, M. Ghafouri, J. G. Nkuimi Wandjou, G. Caprioli, S. Sut, F. Maggi and S. Dall'Acqua, Food Funct., 2019, 10, 7544
    DOI: 10.1039/C9FO01635J

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