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Dihydromyricetin inhibited ovalbumin-induced mice allergic responses by suppressing the activation of mast cells

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Abstract

Dihydromyricetin (DMY) is a natural flavonoid compound derived from Lysionotus pauciflorus Maxim and has been found to possess numerous biological activities. However, there have been few reports regarding its anti-food allergic activity. In this study, we demonstrated that DMY could upregulate the rectal temperature, suppress the development of diarrhea, decrease the levels of serum specific immunoglobulin (Ig)E, histamine, and mouse mast cell protease-1, and promote the production of interleukin-10 in ovalbumin-allergic mice. Moreover, DMY downregulated the population of B cells and mast cells and upregulated the population of regulatory T cells in the spleens of ovalbumin-allergic mice. Furthermore, DMY blocked the high affinity IgE receptor (FcεRI)–IgE interaction, inhibited the release of β-hexosaminidase and histamine in rat basophilic leukemia-2H3 cells, and alleviated passive cutaneous anaphylaxis reactions. These findings indicated that L. pauciflorus derived DMY might have the potential to alleviate food hypersensitivity or allergic diseases.

Graphical abstract: Dihydromyricetin inhibited ovalbumin-induced mice allergic responses by suppressing the activation of mast cells

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Publication details

The article was received on 16 Jul 2019, accepted on 17 Sep 2019 and first published on 18 Sep 2019


Article type: Paper
DOI: 10.1039/C9FO01557D
Food Funct., 2019, Advance Article

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    Dihydromyricetin inhibited ovalbumin-induced mice allergic responses by suppressing the activation of mast cells

    Y. Zhang, Q. Liu, B. Liu, Z. Shu, J. Han, H. Liu, M. Cao, X. Yang, W. Gu and G. Liu, Food Funct., 2019, Advance Article , DOI: 10.1039/C9FO01557D

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