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Issue 10, 2019
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Chemical characterization of the main bioactive polyphenols from the roots of Morus australis (mulberry)

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Abstract

Morus species, commonly known as mulberry, is widely distributed in China. The mulberry tree is a high-value plant in agriculture. Morus australis is one of the major Morus species growing in Northern China. However, the biological properties of the main constituents of M. australis roots were not well studied. In the present study, through extensive chromatographic and spectral analysis, 12 phenolic compounds were isolated and identified from the M. australis roots. Compounds 1, 2, 8, 9 and 12 were isolated from M. australis roots for the first time. Antitumor activities of these polyphenols were studied on the A549 cell line. Compounds 1, 5 and 6 exhibited cytotoxicity on A549 cells and induced apoptosis in A549 cells via the intrinsic mitochondrial pathway. They also mediated inhibition of autophagic flux contributed cell death via the PI3k/Akt/mTOR pathway. In order to explore more potential bioactivities of these isolates, α-glucosidase, acetylcholinesterase and tyrosinase inhibitory activities were studied, and the results demonstrated that the inhibitory activity of these polyphenols on enzymes was not defined by their basic structural skeletons, but by the substituted position.

Graphical abstract: Chemical characterization of the main bioactive polyphenols from the roots of Morus australis (mulberry)

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Publication details

The article was received on 05 Jul 2019, accepted on 13 Sep 2019 and first published on 14 Sep 2019


Article type: Paper
DOI: 10.1039/C9FO01457H
Food Funct., 2019,10, 6915-6926

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    Chemical characterization of the main bioactive polyphenols from the roots of Morus australis (mulberry)

    S. Guo, L. Liu, S. Zhang, C. Yang, W. Yue, H. Zhao, C. Ho, J. Du, H. Zhang and N. Bai, Food Funct., 2019, 10, 6915
    DOI: 10.1039/C9FO01457H

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