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Isoflavones enhance the plasma cholesterol-lowering activity of 7S protein in hypercholesterolemic hamsters

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Abstract

Previous studies have shown that 7S protein is the active ingredient responsible for the plasma cholesterol-lowering activity of soybean. It is hypothesized that isoflavones in soybean could enhance the blood cholesterol-lowering activity of 7S protein. Forty-eight hamsters were divided into six groups and fed a non-cholesterol diet or one of the five high-cholesterol diets containing 12.1% 7S protein with 0–15.62 mg g−1 isoflavones. The results showed that addition of isoflavones in diets dose-dependently enhanced the plasma total cholesterol-lowering activity of 7S protein. Addition of isoflavones in 7S protein-based diets significantly reduced hepatic cholesterol accumulation by 12.6–26.1%, compared with the high cholesterol control diet. Isoflavones could also facilitate excretion of neutral sterols in a dose-dependent manner. Supplementation of isoflavones in diets favourably modulated mRNA expression and the protein mass of HMG-CoA reductase. It was concluded that the enhancing effect of isoflavones on the blood cholesterol-lowering activity of 7S protein was mediated by inhibiting the cholesterol absorption and de novo cholesterol synthesis in hypercholesterolemic hamsters.

Graphical abstract: Isoflavones enhance the plasma cholesterol-lowering activity of 7S protein in hypercholesterolemic hamsters

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Publication details

The article was received on 02 Jul 2019, accepted on 08 Oct 2019 and first published on 10 Oct 2019


Article type: Paper
DOI: 10.1039/C9FO01432B
Food Funct., 2019, Advance Article

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    Isoflavones enhance the plasma cholesterol-lowering activity of 7S protein in hypercholesterolemic hamsters

    Y. Liu, J. Yang, L. Lei, L. Wang, X. Wang, K. Y. Ma, X. Yang and Z. Chen, Food Funct., 2019, Advance Article , DOI: 10.1039/C9FO01432B

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