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Isoflavones enhance plasma cholesterol-lowering activity of 7S protein in hypercholesterolemia hamsters

Abstract

Previous study has shown that 7S-protein is the active ingredient responsible for plasma cholesterol-lowering activity of soybean. It is hypothesized that isoflavone in soybean could enhance blood cholesterol-lowering activity of 7S protein. Forty-eight hamsters were divided into six groups fed a non-cholesterol diet or one of five high-cholesterol diets containing 12.1% 7S protein with 0-15.62 mg/g isoflavones. Results showed that addition of isoflavones into diets dose-dependently enhanced plasma total cholesterol-lowering activity of 7S protein. Addition of isoflavone in 7S protein-based diets significantly reduced hepatic cholesterol accumulation by 12.6-26.1%, compared with HCD diet. Isoflavones could also facilitate excretion of neutral sterols in a dose-dependent manner. Supplementation of Isoflavones in diets favourably modulated mRNA expression and protein mass of HMG-CoA Reductase. It was concluded that the enhancing effect of isoflavones on blood cholesterol-lowering activity of 7S protein was mediated by inhibiting the cholesterol absorption and de novo cholesterol synthesis in hypercholesterolemia hamsters.

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Publication details

The article was received on 02 Jul 2019, accepted on 08 Oct 2019 and first published on 10 Oct 2019


Article type: Paper
DOI: 10.1039/C9FO01432B
Food Funct., 2019, Accepted Manuscript

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    Isoflavones enhance plasma cholesterol-lowering activity of 7S protein in hypercholesterolemia hamsters

    Y. Liu, J. Yang, L. Lei, L. Wang, X. B. Wang, K. Y. Ma, X. Yang and Z. Chen, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C9FO01432B

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