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Protective Effect of Pterostilbene on Concanvalin A-Induced Acute Liver Injury

Abstract

Pterostilbene (PTE) is broadly found in berries with antioxidant and anti-inflammatory properties. To examine the effect of PTE on acute liver injury, mice were administrated with PTE prior to concanavalin A(ConA). Exactly, the mice were divided as follows: (i) vehicle control, (ii) ConA alone, (iii) ConA with PTE at 10 mg/kg (PTE low dose, PTL), and (iv) ConA with PTE at 40 mg/kg (PTE high dose, PTH). After ConA challenge, mice showed prompt induction of intrahepatic INF-γ and TNF-α, followed by tissue factor (TF) which aggravates fibrin deposition and massive liver necrosis whereas these effects were significantly counteracted upon PTE pretreatment. Furthermore, PTE reversed the phosphorylation of ConA-induced intrahepatic inflammatory kinases including JNK, ERK1/2, p38 and p65. Interestingly, PTE didn’t directly act on hepatocytes but inhibit intrahepatic macrophages accumulation and TF generation through inhibiting inflammatory p38 MAPK activation. These results suggest a promising avenue for exploring pterostilbene in improving acute liver injury.

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Publication details

The article was received on 29 Jun 2019, accepted on 23 Sep 2019 and first published on 03 Oct 2019


Article type: Paper
DOI: 10.1039/C9FO01405E
Food Funct., 2019, Accepted Manuscript

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    Protective Effect of Pterostilbene on Concanvalin A-Induced Acute Liver Injury

    J. Wu, M. Li, J. He, K. Lv, M. Wang, W. Guan, J. Liu, Y. Tao, S. Li, C. Ho and H. Zhao, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C9FO01405E

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