Jump to main content
Jump to site search

Issue 11, 2019
Previous Article Next Article

Structural stability of liposome-stabilized oil-in-water pickering emulsions and their fate during in vitro digestion

Author affiliations

Abstract

Most current research on food-relevant Pickering emulsions has been conducted using inorganic or food-compatible organic particles as emulsifiers. A key challenge is maintaining a favourable structure while being able to resist displacement or destabilisation by surfactants and controlling transport of substrates during digestion. Liposome stabilised emulsions have demonstrated some potential for being smart, responsive delivery systems for poorly available bioactives and drugs. We developed a liposome-stabilized oil-in-water Pickering emulsion utilising macromolecular crowding- with polyethylene glycol (PEG). They were pH-controllable and had surfactant-dependent deformability whilst displaying dual delivery routes from both the liposome and oil phases. Dynamic light scattering, confocal microscopy and emulsion stability measurements indicated the liposomes containing 10% PEG at neutral pH remained intact at the interface for extended time. Various degrees of interfacial coverage still existed in the presence of PEG, under acidic environment and with added bile salts. Emulsions with added PEG maintained a more integrated structure after in vitro oral-gastric digestion, and showed greater lipolysis with more free fatty acids (14.7 ± 0.5% for with PEG vs. 12.7 ± 0.1% for without PEG) released during in vitro intestinal digestion. These Pickering emulsions could provide a flexible approach to controlled release under a broad range of conditions.

Graphical abstract: Structural stability of liposome-stabilized oil-in-water pickering emulsions and their fate during in vitro digestion

Back to tab navigation

Publication details

The article was received on 05 May 2019, accepted on 10 Oct 2019 and first published on 10 Oct 2019


Article type: Paper
DOI: 10.1039/C9FO00967A
Food Funct., 2019,10, 7262-7274

  •   Request permissions

    Structural stability of liposome-stabilized oil-in-water pickering emulsions and their fate during in vitro digestion

    W. Liu, J. Liu, L. J. Salt, M. J. Ridout, J. Han and P. J. Wilde, Food Funct., 2019, 10, 7262
    DOI: 10.1039/C9FO00967A

Search articles by author

Spotlight

Advertisements