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Modulating effects of polysaccharides from the fruits of Lycium barbarum on immune response and gut microbiota in cyclophosphamide-treated mice

Abstract

In the present study, the effects of Lycium barbarum polysaccharides (LBPS) on immunoregulation and gut microbiota dysbiosis in cyclophosphamide (CTX)-induced mice were investigated to elucidate whether the attenuation of immunosuppression is related to the modulation of gut microbiota. The results showed that administration of LBPS could protect immune organs (enhancing immune organ indexes and alleviating immune organ damage), enhance the production of immune-related cytokines (IL-2, IL-6, IL-1, TNF- and IFN-) and prevent the hepatotoxicity in CTX-induced mice. Additionally, LBPS treatment could promote the production of short-chain fatty acids and modulate the composition of gut microbiota, increasing the relative abundances of Bacteroidaceae, Lactobacillaceae, Prevotellaceae and Verrucomicrobiaceae, which were positively associated with immune traits. The present results indicated that LBPS might regulate immune response depending on the modulation of gut microbiota, suggesting that LBPS could be developed as special ingredients for immunoregulation in association with the modulation of gut microbiota.

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Supplementary files

Publication details

The article was received on 27 Mar 2019, accepted on 09 May 2019 and first published on 10 May 2019


Article type: Paper
DOI: 10.1039/C9FO00638A
Food Funct., 2019, Accepted Manuscript

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    Modulating effects of polysaccharides from the fruits of Lycium barbarum on immune response and gut microbiota in cyclophosphamide-treated mice

    Y. Ding, Y. Yan, D. Chen, L. Ran, J. Mi, L. Lu, B. Jin, X. Li, X. Zeng and Y. Cao, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C9FO00638A

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