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The chemical composition of a cold-pressed milk thistle seed flour extract, and its potential health beneficial properties

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Abstract

Cold-pressed milk thistle seed flour was extracted with 50% acetone and evaluated for its phytochemical composition, and gut microbiota modulating, free radical scavenging, anti-inflammatory and anti-proliferative capacities. UHPLC-MS analysis detected fifteen compounds in the milk thistle seed flour extract with silychristin as the primary component followed by silybin B and isosilybins A & B. The milk thistle seed flour extract enhanced the total bacteria number and altered the abundance of a specific bacterial phylum or genus under the experimental conditions. The extract had RDSC, ORAC, HOSC, and ABTS˙+ scavenging capacities of 49, 634, 10 420 and 116 μmol Trolox equivalents (TE) per g flour, respectively. In addition, the milk thistle seed flour extract suppressed LPS induced IL-1β mRNA expression in the cultured J774A.1 mouse macrophages and the proliferation of LNCaP prostate cancer cells. The results suggest milk thistle seed flour's potential health benefits in functional foods.

Graphical abstract: The chemical composition of a cold-pressed milk thistle seed flour extract, and its potential health beneficial properties

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Publication details

The article was received on 22 Feb 2019, accepted on 28 Mar 2019 and first published on 29 Mar 2019


Article type: Paper
DOI: 10.1039/C9FO00377K
Citation: Food Funct., 2019, Advance Article

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    The chemical composition of a cold-pressed milk thistle seed flour extract, and its potential health beneficial properties

    U. Choe, Y. Li, B. Gao, L. Yu, T. T. Y. Wang, J. Sun, P. Chen and L. (. Yu, Food Funct., 2019, Advance Article , DOI: 10.1039/C9FO00377K

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