Issue 6, 2019
From the journal:

Food & Function

Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation†

M. A. Ávila-Gálvez, ORCID logo a   J. A. Giménez-Bastida, ORCID logo a   A. González-Sarrías ORCID logo a  and  J. C. Espín ORCID logo *a  

* Corresponding authors

a Laboratory of Food & Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, P.O. Box 164, 30100 Campus de Espinardo, Murcia, Spain
E-mail: jcespin@cebas.csic.es

Abstract

Urolithin A (Uro-A) is an anti-inflammatory and cancer chemopreventive metabolite produced by the gut microbiota from the polyphenol ellagic acid. However, in vivo conjugation of Uro-A to Uro-A glucuronide (Uro-A glur) dramatically hampers its activity. We describe here for the first time the tissue deconjugation of Uro-A glur to Uro-A after lipopolysaccharide (LPS)-induced inflammation, which could explain the systemic in vivo activity of free Uro-A in microenvironments subjected to inflammatory stimuli.

Graphical abstract: Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation

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Article information

DOI
https://doi.org/10.1039/C9FO00298G
Article type
Communication
Submitted
14 Feb 2019
Accepted
18 Apr 2019
First published
24 Apr 2019
This article is Open Access
Creative Commons BY-NC license

Food Funct., 2019,10, 3135-3141

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Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation

M. A. Ávila-Gálvez, J. A. Giménez-Bastida, A. González-Sarrías and J. C. Espín, Food Funct., 2019, 10, 3135 DOI: 10.1039/C9FO00298G

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