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An extensive review on popular functional foods and nutraceuticals against obesity and its related complications with a special focus on randomized clinical trials

Abstract

Obesity is a multifactorial chronic disease or syndrome caused by an imbalance in energy expenditure and intake. Obesity and its associated complications make it has the fifth leading cause for global mortality. The benefits of the current anti-obesity treatment regimen have been masked by high cost and numerous adverse effects. Therefore, many researchers focus on plant-derived/natural products or altered dietary pattern for the management of obesity and its related complications (co-morbidities). Several epidemiological studies also confirmed that the consumption of functional foods/nutraceuticals could considerably lower the risk of various chronic diseases like obesity, diabetic mellitus, and cancer but the underpinning mechanism is still unclear. This comprehensive review brief on the prevalence of obesity, complications related obesity, current treatment regimen and the importance of functional foods and nutraceuticals (molecular mechanism) for the management of body weight and alleviates its co-morbid conditions. This is the first comprehensive review revealing the in-depth anti-obesity mechanism of various popular functional foods and nutraceuticals with special reference to randomized clinical trials (RCTs). Overall, this contribution would signify the importance and beneficial role of functional foods/nutraceuticals on weight management (anti-obesity) to convey the current treatment status related to clinical trials which would help in the development of novel functional foods/nutraceuticals for combatting obesity and its co-morbidities.

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Publication details

The article was received on 13 Feb 2019, accepted on 15 Apr 2019 and first published on 16 Apr 2019


Article type: Review Article
DOI: 10.1039/C9FO00293F
Citation: Food Funct., 2019, Accepted Manuscript

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    An extensive review on popular functional foods and nutraceuticals against obesity and its related complications with a special focus on randomized clinical trials

    K. Venkatakrishnan, H. Chiu and C. K. Wang, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C9FO00293F

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