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Issue 4, 2019
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Attenuation of allergic responses following treatment with resveratrol in anaphylactic models and IgE-mediated mast cells

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Abstract

Resveratrol exists widely in plant species and has a variety of anti-oxidant, anti-inflammatory, and immunomodulatory properties. However, there have been few reports regarding its anti-food allergic activity. In this study, we demonstrated that resveratrol (isolated from Abies georgei) could decrease the release of β-hexosaminidase and histamine in rat basophilic leukemia-2H3 cells. Resveratrol was not only found to suppress the development of diarrhea, up-regulate the rectal temperature of ovalbumin-allergic mice, and decrease the serum level of specific immunoglobulin E, mouse mast cell protease-1 and histamine, but also found to decrease the population of dendritic cells, B cells and mast cells of ovalbumin -allergic mice in the spleen or mesenteric lymph node. Furthermore, resveratrol inhibited the release of β-hexosaminidase and histamine in bone marrow-derived cells and alleviated mast cell-mediated passive cutaneous anaphylaxis reactions. These findings indicated that resveratrol isolated from Abies georgei might have the potential to alleviate food hypersensitivity or allergic disease.

Graphical abstract: Attenuation of allergic responses following treatment with resveratrol in anaphylactic models and IgE-mediated mast cells

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Publication details

The article was received on 14 Jan 2019, accepted on 08 Mar 2019 and first published on 08 Mar 2019


Article type: Paper
DOI: 10.1039/C9FO00077A
Citation: Food Funct., 2019,10, 2030-2039

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    Attenuation of allergic responses following treatment with resveratrol in anaphylactic models and IgE-mediated mast cells

    Y. Zhang, Q. Liu, Y. Gao, B. Liu, H. Liu, M. Cao, X. Yang and G. Liu, Food Funct., 2019, 10, 2030
    DOI: 10.1039/C9FO00077A

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