Issue 5, 2019

Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy

Abstract

Recurrent cardiotoxicity limits the clinical application of doxorubicin (DOX); however the detailed molecular mechanism of DOX cardiotoxicity remains unclear. In the current study, we found that a natural product extracted from Illicium verum, isodunnianol (IDN), mitigates DOX-induced cardiotoxicity by regulating autophagy and apoptosis both in vitro and in vivo. DOX suppressed protective autophagy and induced apoptosis in H9C2 cardiac myoblasts. Additionally, IDN demonstrated up-regulated autophagy and reduced apoptosis through the activation of the AMPKā€“ULK1 pathway. In addition, the beneficial effects of IDN on DOX which induced myocardial injury were dependent on AMPK and ULK1 phosphorylation. Similar results were also observed in a DOX-induced cardiotoxicity rat model. The combination of IDN and DOX resulted in decreased apoptosis and inflammatory myocardial fibrosis compared to the DOX mono-treatment group. In summary, our findings provide novel insights into the prevention of DOX-related toxicity by isodunnianol, a food source natural product, warranting further investigation.

Graphical abstract: Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy

Supplementary files

Article information

Article type
Paper
Submitted
10 Jan 2019
Accepted
07 Apr 2019
First published
08 Apr 2019

Food Funct., 2019,10, 2651-2657

Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy

C. Chen, L. Jiang, M. Zhang, X. Pan, C. Peng, W. Huang and Q. Jiang, Food Funct., 2019, 10, 2651 DOI: 10.1039/C9FO00063A

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