Essential oil of Schisandra Chinensis Fructus ameliorates cognitive decline in mouse by alleviating inflammation
ABSTRAT：This work was to assess possible impacts of essential oil (SEO) from Schisandra chinensis Baill fruits (S. chinensis) on mice with cognition impairment. Our data showed that SEO improved the cognitive ability of Aβ1-42 or lipopolysaccharides (LPS）induced Alzheimer’s disease (AD) mice and suppressed production of tumor necrosis factor-a (TNF-a), and interleukin-6 (IL-6), and interleukin-1β (IL-1β) in the hippocampus. Furthermore, SEO inhibited p38 activation, but had little effect on other signaling protein in MAPK family, extracellular signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase 1/2 (JNK). Furthermore, we used SEO and BV-2 microglia co-culture to further verify its anti-inflammatory activity. From the results, SEO also decreased the nitric oxide (NO) in LPS-stimulated BV-2 microglia and significantly blocked LPS-induced MAPKs activation. Taken together, these findings suggest that SEO exerts anti-AD effects in AD mice partly by modulating neuroinflammation through NF-κB/MAPK signaling pathway.