Jump to main content
Jump to site search

Issue 2, 2019
Previous Article Next Article

Inhibitory effect of Athelia rolfsii exopolysaccharides on organ damage in lead-exposed Kunming strain mice

Author affiliations

Abstract

Herein, Athelia rolfsii exopolysaccharides (AEPS) were used to alleviate organ damage in lead-exposed mice. Analysis of the body weight growth rate and visceral index revealed that AEPS maintained the normal body weight growth rates in lead-exposed mice. Biochemical indicators (T-SOD, CAT, MDA) in serum revealed that AEPS increased the activity of T-SOD in the serum of lead-exposed mice. The lead concentrations in the brain, liver, kidneys, testis and faeces were measured by flame atomic absorption. The percent reductions in lead accumulation in these organs were 76.65% (brain), 60.42% (liver), 78.43% (kidneys) and 56.47% (testis). The data suggest that a significant portion of the lead was expelled in the faeces. The results proved that AEPS prevented lead accumulation in the organs of lead-exposed mice. A histological evaluation of the brain, liver, kidneys and testis also revealed that AEPS significantly alleviated liver and kidney damage caused by lead poisoning and protected neurons and sperm cells. We hypothesize that the ingested AEPS chelated the lead in the digestive system of the mice, leading to excretion through the faeces. Thus, AEPS represent a promising method of detoxification following lead poisoning.

Graphical abstract: Inhibitory effect of Athelia rolfsii exopolysaccharides on organ damage in lead-exposed Kunming strain mice

Back to tab navigation

Publication details

The article was received on 25 Dec 2018, accepted on 24 Jan 2019 and first published on 25 Jan 2019


Article type: Paper
DOI: 10.1039/C8FO02558D
Citation: Food Funct., 2019,10, 1159-1166

  •   Request permissions

    Inhibitory effect of Athelia rolfsii exopolysaccharides on organ damage in lead-exposed Kunming strain mice

    B. Li, H. Li, Y. Gao, C. Fan and W. Min, Food Funct., 2019, 10, 1159
    DOI: 10.1039/C8FO02558D

Search articles by author

Spotlight

Advertisements