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Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk

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Abstract

Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.

Graphical abstract: Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk

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Publication details

The article was received on 02 Dec 2018, accepted on 18 Dec 2018 and first published on 04 Jan 2019


Article type: Communication
DOI: 10.1039/C8FO02376J
Citation: Food Funct., 2019, Advance Article
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    Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk

    R. Mukherjee, M. van de. Kaa, J. Garssen, R. J. Pieters, A. D. Kraneveld and L. E. M. Willemsen, Food Funct., 2019, Advance Article , DOI: 10.1039/C8FO02376J

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