Jump to main content
Jump to site search


Establishing the impact of food matrix effects on the bioaccessibility of nutraceuticals and pesticides using a standardized food model

Author affiliations

Abstract

It is important to establish the impact of food matrix effects on the bioaccessibility of co-ingested substances, such as nutraceuticals, engineered nanomaterials, pharmaceuticals, and pesticides. Recently, a standardized food model (SFM) representing a typical US diet has been developed to facilitate these investigations. This model consists of caseinate-stabilized fat droplets, free casein, pectin, starch, sucrose, and sodium chloride. The SFM was stable to creaming for 2 days, contained small particles (d ≈ 180 nm), and had a narrow particle size distribution. The SFM was mixed with pureed tomato that had been deliberately contaminated with chlorpyrifos (a hydrophobic pesticide). The resulting mixture was then exposed to an in vitro digestion model. The structural and physicochemical characteristics of the samples (microstructure, particle diameter, and surface potential) were determined after each GIT stage. Also, the bioaccessibility of both chlorpyrifos and lycopene (a hydrophobic nutraceutical) from the pesticide-contaminated tomatoes was determined after the final digestion process. For lycopene, the bioaccessibility was much lower for tomato alone (0.75%) than for tomato plus SFM (19.0%) (p < 0.05). For chlorpyrifos, the bioaccessibility was also appreciably lower for tomato alone (40.4%) than for tomato plus SFM (58.7%), but the effect was less dramatic (p < 0.05). Our results indicate that a standardized food matrix impacts the bioaccessibility of hydrophobic bioactives in fresh produce by an amount that depends on the nature of the bioactive agent. The SFM developed here may therefore be useful for screening the potential impact of food matrix effects on the bioaccessibility of ingested bioactives and other substances.

Graphical abstract: Establishing the impact of food matrix effects on the bioaccessibility of nutraceuticals and pesticides using a standardized food model

Back to tab navigation

Publication details

The article was received on 30 Nov 2018, accepted on 30 Jan 2019 and first published on 31 Jan 2019


Article type: Paper
DOI: 10.1039/C8FO02368A
Citation: Food Funct., 2019, Advance Article

  •   Request permissions

    Establishing the impact of food matrix effects on the bioaccessibility of nutraceuticals and pesticides using a standardized food model

    Z. Zhang, R. Zhang and D. J. McClements, Food Funct., 2019, Advance Article , DOI: 10.1039/C8FO02368A

Search articles by author

Spotlight

Advertisements