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Effects of Probiotic Supplementation Regulating Blood Lipid Levels in Overweight or Obese Subjects: A Meta-analysis

Abstract

Abstract Background: Obesity is a risk factor for many deadly diseases. Meanwhile, the prevalence of obesity has been continuously increasing in many countries. Probiotics are defined as live microorganisms that confer health benefits on hosts. Probiotic supplementation could reduce body weight, body mass index (BMI) and fat percentage. However, it is unclear whether supplementation with probiotics is beneficial to lower blood lipid levels for obese or overweight people. Methods: In this study, a comprehensive search across multiple databases was performed to identify studies focused on the effects of probiotics on blood lipid levels in overweight or obese subjects. The meta-analysis included studies that compared the variations in blood lipid(total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglyceride (TG)) concentrations between overweight and obese subjects who supplemented with probiotics versus controls who were not supplemented with probiotics. Results: Our findings indicated that probiotic supplementation in obese or overweight people was associated with significantly larger reductions in TC and LDL levels compared to a lack of probiotic supplementation in control subjects. However, there was no significant difference in the variations between HDL and TG concentrations. Conclusion: Probiotic supplementation reduced TC and LDL concentrations in obese or overweight people. Additional data from large clinical trials is required to confirm the efficacy and safety of probiotics for regulating blood lipid levels in obese or overweight people.

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Publication details

The article was received on 03 Nov 2018, accepted on 18 Jan 2019 and first published on 04 Feb 2019


Article type: Review Article
DOI: 10.1039/C8FO02163E
Citation: Food Funct., 2019, Accepted Manuscript
  • Open access: Creative Commons BY-NC license
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    Effects of Probiotic Supplementation Regulating Blood Lipid Levels in Overweight or Obese Subjects: A Meta-analysis

    S. Yan, Z. Tian, M. Li, B. Li and W. Cui, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C8FO02163E

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