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From white to beige adipocytes: therapeutic potential of dietary molecules against obesity and their molecular mechanisms

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Abstract

The global incidence of obesity and its complications continue to rise along with a demand for novel therapeutic approaches. In addition to classic brown adipose tissue (BAT), the formation of brown-like adipocytes called beige adipocytes, within white adipose tissue (WAT), has attracted much attention as a therapeutic target due to its inducible features when stimulated, resulting in the dissipation of extra energy as heat. There are various dietary agents that are able to modulate the beige-development process by interacting with critical molecular signaling cascades, leading to the enhancement of thermogenesis. Although challenges still remain regarding the origin of the beige adipocytes, the crosstalk with activation of BAT and induction of the beiging of white fat may provide attractive potential strategies for management of obesity.

Graphical abstract: From white to beige adipocytes: therapeutic potential of dietary molecules against obesity and their molecular mechanisms

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Publication details

The article was received on 02 Nov 2018, accepted on 21 Jan 2019 and first published on 21 Jan 2019


Article type: Review Article
DOI: 10.1039/C8FO02154F
Citation: Food Funct., 2019, Advance Article

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    From white to beige adipocytes: therapeutic potential of dietary molecules against obesity and their molecular mechanisms

    S. Wang, M. Pan, W. Hung, Y. Tung and C. Ho, Food Funct., 2019, Advance Article , DOI: 10.1039/C8FO02154F

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