Jump to main content
Jump to site search


Supplementation with Lactobacillus kefiranofaciens ZW3 from Tibetan Kefir improves depression-like behavior in stressed mice by modulating the gut microbiota

Author affiliations

Abstract

Increasing evidence indicates that probiotics can effectively improve depression-like behavior. However, the underlying mechanism is still unclear. In this study, the antidepressant effect of Lactobacillus kefiranofaciens CGMCC2809 (ZW3) isolated from Tibetan Kefir grains was investigated using a mouse model of chronic unpredictable mild stress (CUMS). ZW3 improved depression-like behavior and independent exploration ability in the CUMS group. Moreover, ZW3 regulated biochemical disorders in the hypothalamic–pituitary–adrenal axis, immune system and tryptophan metabolism caused by stress. Furthermore, ZW3 could modulate the composition of the gut microbiota, and alleviate constipation by improving the fecal water content in stressed mice. We found that the probiotic strain was present in the whole intestine, even 7 days after its administration was stopped. These results suggest that L. kefiranofaciens ZW3 might improve depression by regulating the gut microbiota as a probiotic food.

Graphical abstract: Supplementation with Lactobacillus kefiranofaciens ZW3 from Tibetan Kefir improves depression-like behavior in stressed mice by modulating the gut microbiota

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Oct 2018, accepted on 13 Jan 2019 and first published on 14 Jan 2019


Article type: Paper
DOI: 10.1039/C8FO02096E
Citation: Food Funct., 2019, Advance Article

  •   Request permissions

    Supplementation with Lactobacillus kefiranofaciens ZW3 from Tibetan Kefir improves depression-like behavior in stressed mice by modulating the gut microbiota

    Y. Sun, W. Geng, Y. Pan, J. Wang, P. Xiao and Y. Wang, Food Funct., 2019, Advance Article , DOI: 10.1039/C8FO02096E

Search articles by author

Spotlight

Advertisements