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Beneficial Effects of Tea Water Extracts on Body Weight and Gut Microbiota in C57BL/6J Mice Fed a High-fat Diet

Abstract

Accumulative evidence has suggested that tea consumption has benefits in reducing body fat and alleviating metabolic syndrome. We hypothesize that benefits of tea consumption be partially mediated by modulating intestinal microbiota via inhibiting the formation of lipopolysaccharides (LPS) and promoting the production of short chain fatty acids (SCFAs). C57BL/6J mice were fed a high-fat diet with addition 1% water extracts of green tea, oolong tea and black tea. Results showed that the dietary supplementation of three tea water extracts equally improved the glucose tolerance and reduced a high fat diet-induced gain in weight, hepatic lipids, and white adipose tissues weights. This was accompanied by a significant reduction in plasma LPS and a significant increase in production of SCFAs. The metagenomic analysis showed that the tea extracts changed the overall composition of gut microbiota and decreased the relative abundance of family Rikenellaceae and Desulfovibrionaceae. In addition, tea water extracts could also change the abundance of key OTUs including OTU473 (Alistipes), OTU229 (Rikenella), OTU179 (Ruminiclostridium) and OTU264 (Acetatifactor). In conclusion, three tea extracts could improve the glucose tolerance, induce the production of SCFAs and inhibit the production of endotoxin LPS, most likely mediated by modulating gut microbiota.

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Publication details

The article was received on 20 Oct 2018, accepted on 15 Apr 2019 and first published on 16 Apr 2019


Article type: Paper
DOI: 10.1039/C8FO02051E
Citation: Food Funct., 2019, Accepted Manuscript

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    Beneficial Effects of Tea Water Extracts on Body Weight and Gut Microbiota in C57BL/6J Mice Fed a High-fat Diet

    J. Liu, W. Hao, Z. He, E. Kwek, Y. Zhao, H. Zhu, N. Liang, K. Y. Ma, L. LEI, W. He and Z. Chen, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C8FO02051E

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