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Issue 2, 2019
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The effects of polyphenols and other bioactives on human health

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Abstract

Although deficiencies in polyphenol intake do not result in specific deficiency diseases, adequate intake of polyphenols could confer health benefits, especially with regard to chronic diseases. Tea, cocoa, fruits, and berries, as well as vegetables, are rich in polyphenols. Flavan-3-ols from cocoa have been found to be associated with a reduced risk of stroke, myocardial infarction, and diabetes, as well as improvements in lipids, endothelial-dependent blood flow and blood pressure, insulin resistance, and systemic inflammation. The flavonoid quercetin and the stilbene resveratrol have also been associated with cardiometabolic health. Although polyphenols have been associated with improved cerebral blood flow, evidence of an impact on cognition is more limited. The ability of dietary polyphenols to produce clinical effects may be due, at least in part, to a bi-directional relationship with the gut microbiota. Polyphenols can impact the composition of the gut microbiota (which are independently associated with health benefits), and gut bacteria metabolize polyphenols into bioactive compounds that produce clinical benefits. Another critical interaction is that of polyphenols with other phytochemicals, which could be relevant to interpreting the health parameter effects of polyphenols assayed as purified extracts, whole foods, or whole food extracts.

Graphical abstract: The effects of polyphenols and other bioactives on human health

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Publication details

The article was received on 12 Oct 2018, accepted on 05 Jan 2019 and first published on 12 Feb 2019


Article type: Review Article
DOI: 10.1039/C8FO01997E
Citation: Food Funct., 2019,10, 514-528
  • Open access: Creative Commons BY-NC license
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    The effects of polyphenols and other bioactives on human health

    C. G. Fraga, K. D. Croft, D. O. Kennedy and F. A. Tomás-Barberán, Food Funct., 2019, 10, 514
    DOI: 10.1039/C8FO01997E

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