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Issue 2, 2019
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α-Ionone attenuates high-fat diet-induced skeletal muscle wasting in mice via activation of cAMP signaling

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Abstract

Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacological therapy. Our aim was to investigate the potential of α-ionone, a naturally occurring flavoring agent, in preventing muscle atrophy and to delineate the mechanisms involved. We found that α-ionone not only stimulated myogenesis but also attenuated palmitic-acid-induced atrophy of cultured skeletal myotubes, as evidenced by an increased myotube diameter and length, fusion index, and cellular protein content. These beneficial actions of α-ionone were abrogated by cAMP inhibitor. The antiatrophic effects of α-ionone on cultured myotubes were confirmed in a corresponding mouse model. The skeletal muscle mass, muscle protein content, myofiber diameter, and muscle strength were greater in α-ionone-treated mice than in untreated animals fed high-fat diet. Furthermore, α-ionone increased cAMP concentration and enhanced its downstream PKA-CREB signaling in skeletal muscle of mice fed high-fat diet. Thus, α-ionone is a promising agent that may enhance skeletal muscle mass and strength.

Graphical abstract: α-Ionone attenuates high-fat diet-induced skeletal muscle wasting in mice via activation of cAMP signaling

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Publication details

The article was received on 12 Oct 2018, accepted on 03 Feb 2019 and first published on 05 Feb 2019


Article type: Paper
DOI: 10.1039/C8FO01992D
Citation: Food Funct., 2019,10, 1167-1178

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    α-Ionone attenuates high-fat diet-induced skeletal muscle wasting in mice via activation of cAMP signaling

    T. Tong, M. Kim and T. Park, Food Funct., 2019, 10, 1167
    DOI: 10.1039/C8FO01992D

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