Jump to main content
Jump to site search


Alpha-lipoic acid and its protective role in fructose induced endocrine-metabolic disturbances

Author affiliations

Abstract

In recent decades a worldwide increase has been reported in the consumption of unhealthy high calorie diets associated with marked changes in meal nutrient composition, such as a higher intake of refined carbohydrates, which leads to the speculatation that changes in food habits have contributed to the current epidemic of obesity and type 2 diabetes. Among these refined carbohydrates, fructose has been deeply investigated and murine models of high fructose diet have emerged as useful tools to study dietary-induced insulin resistance, impaired glucose tolerance, dyslipidemia and alterations in glucose metabolism. Since oxidative stress has been demonstrated to play a key pathogenic role in the alterations described above, several lines of research have focused on the possible preventive effects of antioxidant/redox state regulation therapy, among which alpha-lipoic acid has been extensively investigated. The following references discussed support the fact that co-administration of alpha-lipoic acid normalized the changes generated by fructose rich diets, thereby making this compound a good therapeutic tool, also administered as a food supplement, to prevent endocrine–metabolic disturbances triggered by high fructose associated with obesity and type 2 diabetes at an early stage of development (prediabetes).

Graphical abstract: Alpha-lipoic acid and its protective role in fructose induced endocrine-metabolic disturbances

Back to tab navigation

Publication details

The article was received on 21 Sep 2018, accepted on 03 Dec 2018 and first published on 04 Dec 2018


Article type: Review Article
DOI: 10.1039/C8FO01856A
Citation: Food Funct., 2019, Advance Article
  •   Request permissions

    Alpha-lipoic acid and its protective role in fructose induced endocrine-metabolic disturbances

    M. C. Castro, H. G. Villagarcía, M. L. Massa and F. Francini, Food Funct., 2019, Advance Article , DOI: 10.1039/C8FO01856A

Search articles by author

Spotlight

Advertisements