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Impact of different level of Cysteine on the plasma metabolomics and intestinal microflora of the sow during late pregnancy

Abstract

Cysteine (Cys) is a semi-essential amino acid that can be synthesized from human and animal methionine and affects the specific physiological state of mammals. This study aims to investigate the effects of different level of Cys on the birth weight of piglet, biochemical parameters in plasma, intestinal microbial and plasma metabolism of sows during late pregnancy. The results showed that 0.4% Cys group improved the birth weight of piglets and decreased the level of calcium, triglyceride and bilirubin, but 0.5% Cys group reduced the activity of gamma-glutamyl transpeptidase and increased the concentration of glucose of sows at the point of farrowing. The result of intestinal microbial analysis showed that 0.4% Cys group increased the diversity of faecal intestinal microbes compared with 0.5% Cys group. In addition, plasma metabolomic results differentiated that the three group of sows and eleven discriminating metabolites were identified. 0.4% and 0.5% Cys group increased the hypotaurine, 0.5% Cys group increased the acetylcysteine, and there was no significant difference between 0.4% and 0.5% Cys group. Moreover, the Pearson analysis revealed a positive correlation between hypotanaurine and Lactobacillus or Pseudobutyrivibrio, respectively. However, there is a negative correlation between acetylcysteine and Ruminococcaceae_UCG-014. These results revealed that 0.4% Cys group increased the birth weight of piglets, increased the differential metabolites beneficial to the antioxidant stress of embryos and the enhancement of microbial abundance, and increased the diversity of fecal microbe, which demonstrated that 0.4% Cys is better for sow to maintain the health status during the late pregnancy.

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Publication details

The article was received on 19 Sep 2018, accepted on 21 Dec 2018 and first published on 05 Jan 2019


Article type: Paper
DOI: 10.1039/C8FO01838C
Citation: Food Funct., 2019, Accepted Manuscript
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    Impact of different level of Cysteine on the plasma metabolomics and intestinal microflora of the sow during late pregnancy

    S. Ding, J. Fang, G. Liu, D. Veeramuthu, A. N.A. and Y. Yin, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C8FO01838C

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