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Effect of iron supplement from microalgae on the treatment of iron-deficient anemia in rats

Abstract

Microalgae are potential iron supplements for iron deficiency improvement with unknown mechanism. To analyze the enhancement of non-heme iron absorption by microalgae, in current paper, six different microalgal feeds were prepared as main source of dietary iron with 25 mg/kg iron from Spirulina, Chlorella and Synechococcus sp. PCC 7002 (named as H-Sp, H-Ch and H-Sy, respectively) or portion source of dietary iron with 5 mg/kg iron from these three microalgae (named as L-Sp, L-Ch and L-Sy, respectively) to subdue iron deficiency anemia in rats. The hemoglobin regeneration efficiencies in anemic rats followed the order: ferric citrate (34.7 ± 1.8%) < H-Ch (49.9 ± 4.1%) ≈ H-Sy (50.6 ± 5.3%) ≈ L-Sp (46.9 ± 6.2%) ≈ L-Ch (43.1 ± 6.9%) ≈ L-Sy (43.5 ± 2.4%) ≈ FeSO4 (47.2 ± 4.9%) < H-Sp (54.8 ± 5.5%). The percentage content of intestinal nanosized iron in the groups of H-Sp, H-Ch and H-Sy was significantly higher than that in L-Sp, L-Ch and L-Sy groups; moreover, it was significantly higher in groups of microalgal diets than in the ferric citrate group, providing strong evidence for nanosized iron supplementation from microalgae. Overall, microalgae, especially Spirulina, are functional iron nutritive fortifiers which could supply more intestinal nanosized iron.

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Publication details

The article was received on 18 Sep 2018, accepted on 26 Dec 2018 and first published on 10 Jan 2019


Article type: Paper
DOI: 10.1039/C8FO01834K
Citation: Food Funct., 2019, Accepted Manuscript
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    Effect of iron supplement from microalgae on the treatment of iron-deficient anemia in rats

    F. Gao, W. Guo, M. Zeng, Y. Feng and G. Feng, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C8FO01834K

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