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Issue 2, 2019
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One-step assembly of zein/caseinate/alginate nanoparticles for encapsulation and improved bioaccessibility of propolis

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Abstract

The design of zein-based nanoparticles to encapsulate bioactive molecules has gained great attention in recent years. However, the use of ethanol to dissolve zein presents flammability concerns and the scale-up production of zein-based nanoparticles is also a concern. In our study, propolis loaded zein/caseinate/alginate nanoparticles were fabricated using a facile one-step procedure: a well-blended solution was prepared containing deprotonated propolis, soluble zein, dissociated sodium caseinate micelles (NaCas) and alginate at alkaline pH, and then this alkaline solution was added to 0.1 M citrate buffer (pH 3.8) to fabricate composite nanoparticles without using organic solvents and sophisticated equipment. During acidification, the alginate molecules adsorbed on the zein/NaCas surfaces by electrostatic complexation, which improved the stability towards aggregation of zein/NaCas nanoparticles under gastrointestinal (GI) or acidic pH. The nanoparticles prepared under the optimized method (method 3 sample) were of spherical morphology with a particle size around 208 nm and a negative zeta potential around −27 mV. The encapsulation efficiency (EE) and loading capacity (LC) of propolis reached 86.5% and 59.6 μg mg−1 by zein/NaCas/alginate nanoparticles, respectively. These nanoparticles were shown to be stable towards aggregation over a wide range of pH values (2–8) and salt concentrations (0–300 mM NaCl). Compared to free propolis, the bioaccessibility of propolis encapsulated with nanoparticles was increased to 80%. Our results showed a promising clean and scalability strategy to encapsulate hydrophobic nutraceuticals for applications in foods, supplements, and pharmaceuticals.

Graphical abstract: One-step assembly of zein/caseinate/alginate nanoparticles for encapsulation and improved bioaccessibility of propolis

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Publication details

The article was received on 12 Aug 2018, accepted on 22 Dec 2018 and first published on 26 Dec 2018


Article type: Paper
DOI: 10.1039/C8FO01614C
Citation: Food Funct., 2019,10, 635-645

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    One-step assembly of zein/caseinate/alginate nanoparticles for encapsulation and improved bioaccessibility of propolis

    H. Zhang, Y. Fu, Y. Xu, F. Niu, Z. Li, C. Ba, B. Jin, G. Chen and X. Li, Food Funct., 2019, 10, 635
    DOI: 10.1039/C8FO01614C

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