Jump to main content
Jump to site search


Theanine attenuates memory impairments induced by klotho gene depletion in mice

Author affiliations

Abstract

Theanine (γ-glutamylethylamide), an amino acid in tea, is a putative neuroprotective and antioxidant compound capable of improving lifespan and cognitive function. Because we previously reported cognitive dysfunction in klotho mutant mice via down-regulation of janus kinase 2 (JAK2) and signal transducer and activator of transcription3 (STAT3), M1 muscarinic cholinergic receptor (M1 mAChR), and ERK signaling, we, therefore, investigated whether self-administration of theanine affects memory dysfunction in response to klotho gene depletion in mice, and whether theanine modulates the JAK2/STAT3, M1 mAChR, and ERK signaling network. Theanine significantly attenuated memory impairments in klotho mutant mice. Moreover, theanine self-administration significantly attenuated inhibitions of JAK2/STAT3 phosphorylation, M1 mAChR expression, and ERK1/2 phosphorylation in the hippocampus of klotho mutant mice. Consistently, AG490, a JAK2/STAT3 inhibitor, dicyclomine, an M1 mAChR antagonist, or U0126, an ERK1/2 inhibitor, significantly counteracted theanine-induced attenuation of memory impairment induced by klotho gene depletion in mice. Our study suggests that theanine attenuates memory impairments in a genetic aging model via up-regulation of JAK2/STAT3, M1 mAChR, and ERK signaling.

Graphical abstract: Theanine attenuates memory impairments induced by klotho gene depletion in mice

Back to tab navigation

Publication details

The article was received on 06 Aug 2018, accepted on 02 Dec 2018 and first published on 14 Dec 2018


Article type: Paper
DOI: 10.1039/C8FO01577E
Citation: Food Funct., 2019, Advance Article
  •   Request permissions

    Theanine attenuates memory impairments induced by klotho gene depletion in mice

    B. T. Nguyen, N. Sharma, E. Shin, J. H. Jeong, S. H. Lee, C. Jang, S. Nah, T. Nabeshima, Y. Yoneda and H. Kim, Food Funct., 2019, Advance Article , DOI: 10.1039/C8FO01577E

Search articles by author

Spotlight

Advertisements