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Charge-tuning of glycosaminoglycan-based hydrogels to program cytokine sequestration

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Abstract

Glycosaminoglycan (GAG)-based biohybrid hydrogels of varied GAG content and GAG sulfation pattern were prepared and applied to sequester cytokines. The binding of strongly acidic and basic cytokines correlated with the integral space charge density of the hydrogel, while the binding of weakly charged cytokines was governed by the GAG sulfation pattern.

Graphical abstract: Charge-tuning of glycosaminoglycan-based hydrogels to program cytokine sequestration

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Publication details

The article was received on 11 Feb 2019, accepted on 22 Feb 2019 and first published on 22 Feb 2019


Article type: Paper
DOI: 10.1039/C9FD00016J
Faraday Discuss., 2019, Advance Article

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    Charge-tuning of glycosaminoglycan-based hydrogels to program cytokine sequestration

    U. Freudenberg, P. Atallah, Y. D. P. Limasale and C. Werner, Faraday Discuss., 2019, Advance Article , DOI: 10.1039/C9FD00016J

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