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Binary polymer brush patterns from facile initiator stickiness for cell culturing

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Abstract

We report a new initiator stickiness method to fabricate micropatterned binary polymer brush surfaces, which are ideal platforms for studying cell adhesion behavior. The atom transfer radical polymerization (ATRP) initiator, ω-mercaptoundecyl bromoisobutyrate (MUDBr), is found to adsorb on several hosting polymer brushes, including poly[oligo(ethylene glycol)methyl ether methacrylate] (POEGMA), poly(2-hydroxyethyl methacrylate) (PHEMA), and poly(glycidyl methacrylate) (PGMA) brushes. Based on the initiator stickiness, micropatterned initiator molecules are printed onto a layer of homogenous hosting polymer brushes via microcontact printing (μCP), and then, vertically, a patterned second layer of polymer brushes is grown from the initiator areas. With this simple, fast, and additive method, we demonstrate the fabrication of various binary polymer brushes, and show their applications for patterning cell microarrays and controlling cell orientation. This new approach to generating binary polymer brushes shows great potential for the manipulation of interfacial phenomena, facilitating a range of applications from semiconductors and lubrication to fundamental cell biology studies.

Graphical abstract: Binary polymer brush patterns from facile initiator stickiness for cell culturing

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Publication details

The article was received on 05 Feb 2019, accepted on 08 Mar 2019 and first published on 08 Mar 2019


Article type: Paper
DOI: 10.1039/C9FD00013E
Faraday Discuss., 2019, Advance Article

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    Binary polymer brush patterns from facile initiator stickiness for cell culturing

    L. Chen, P. Li, X. Lu, S. Wang and Z. Zheng, Faraday Discuss., 2019, Advance Article , DOI: 10.1039/C9FD00013E

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