Jump to main content
Jump to site search


Binary Polymer Brush Patterns from Facile Initiator-Stickiness for Cell Culturing

Abstract

We report a new initiator-stickiness method to fabricate micropatterned binary polymer brush surfaces, which are ideal platforms for studying cell adhesion behavior. The atom transfer radical polymerization (ATRP) initiator, ω-mercaptoundecyl bromoisobutyrate (MUDBr), is found to adsorb on several hosting polymer brushes including poly [oligo (ethylene glycol) methyl ether methacrylate] (POEGMA), poly (2-hydroxyethyl methacrylate) (PHEMA) and poly (glycidyl methacrylate) (PGMA) brushes. Based on the initiator-stickiness ability, micropatterned initiator molecules are printed onto a first layer of homogenous hosting polymer brush via microcontact printing (μCP), and then vertically a patterned second-layer of polymer brushes are grown from the initiator areas. With this simple, fast and additive method, we demonstrate the fabrication of various binary polymer brushes, and show their applications for patterning cell microarrays and controlling the cell orientation. This new approach to generating binary polymer brushes shows great potential for the manipulation of interfacial phenomena in facilitating a range amount of applications from semiconductor, lubrication to fundamental cell biology study.

Back to tab navigation

Publication details

The article was received on 05 Feb 2019, accepted on 08 Mar 2019 and first published on 08 Mar 2019


Article type: Paper
DOI: 10.1039/C9FD00013E
Citation: Faraday Discuss., 2019, Accepted Manuscript

  •   Request permissions

    Binary Polymer Brush Patterns from Facile Initiator-Stickiness for Cell Culturing

    Z. Zheng, L. Chen, P. Li, X. Lu and S. Wang, Faraday Discuss., 2019, Accepted Manuscript , DOI: 10.1039/C9FD00013E

Search articles by author

Spotlight

Advertisements