Jump to main content
Jump to site search


Interactions between Polystyrene Nanoparticles and Supported Lipid Bilayers: Impact of Charge and Hydrophobicity Modification by Specific Anions

Abstract

Understanding how surface forces and aqueous ions influence the interactions between nanoparticles (NPs) and supported lipid bilayers (SLB) is central to all disciplines interested in studying the nano-bio interface. A prevailing understanding is that cationic NPs have higher penetrating capability across cell membranes. In contrast, we report in this study that anionic polystyrene NPs are capable of binding and penetrating SLB formed by zwitterionic DOPC when charge and hydrophobicity work in concert with specific anions. The preferential deposition of anionic NPs into the bilayer is rationalized electrostatically by considering the slightly positive charge of DOPC. In addition to charge, NP hydrophobicity played an important role in the subsequent penetration of anionic NPs into SLB. The extent of NP deposition was modulated by chaotropic anions (NO3). This study also demonstrates the promise of using a novel combination of surface sensitive techniques, quartz crystal microbalance with dissipation monitoring (QCM-D) and surface-enhanced infrared absorption spectroscopy (SEIRAS), to extend current understanding of NP-SLB interactions to the molecular scale.

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 Jan 2019, accepted on 10 Apr 2019 and first published on 11 Apr 2019


Article type: Paper
DOI: 10.1039/C9EN00055K
Citation: Environ. Sci.: Nano, 2019, Accepted Manuscript

  •   Request permissions

    Interactions between Polystyrene Nanoparticles and Supported Lipid Bilayers: Impact of Charge and Hydrophobicity Modification by Specific Anions

    Z. Xia, A. Woods, I. J. Burgess and B. L. T. Lau, Environ. Sci.: Nano, 2019, Accepted Manuscript , DOI: 10.1039/C9EN00055K

Search articles by author

Spotlight

Advertisements